Caffeine is a chemical compound which acts as a stimulant when consumed. The question is, is this a personal preference? Or if you have problems falling asleep even if you drink coffee earlier in the day, then this is another sign, although of course the sleep problems can be related to something else. I hadn't realized the effects caffeine was having on me until I begin to pay attention to the side effects after seeing that report. This tiny variation makes you either a slow or fast metabolizer of caffeine ¬– it regulates how efficiently your liver breaks down and flushes caffeine from your system. A different variant will make you a slow metabolizer. For this, people adopt many tricks, many of which are successful and many fail. In other words, some slow metabolizers might be adversely affected by caffeine where others aren’t, and the opposite might be true for fast metabolizers. Now you know how to boost metabolism. Other more recent research seems to point in the same direction. We are obsessed with gene-substance interaction. Yes, whose metabolism will be fast and good, he is always fit and he can digest heavy to heavy food in no time. When you have a fast metabolism, your mind and body are able to stay youthful and strong. The fast metabolizers rode nearly 7 percent faster after they had downed the larger dose of caffeine compared to the placebo. Individuals who have two copies of the fast CYP1A2*1A allele are fast caffeine metabolizers; whereas people who have at least one copy of the slow CYP1A2*1F allele are slow caffeine metabolizers. Caffeine is a popular stimulant that impacts the central nervous system. Fast caffeine metabolizers are more likely to benefit from the polyphenols in coffee and are less likely to experience any side effects associated with caffeine since it’s cleared fast enough for it to not be a problem. But how can you tell if you are a “slow” or “fast” metabolizer of caffeine? Read on to find out if you have a fast or slow metabolism, then get my best tips on how to rev it up fast… Signs Your Metabolism Is Supercharged. ; Low Sensitivity to Caffeine: These people have very … Sort by. Slow metabolizers may experience negative side effects of caffeine consumption to a higher degree such as insomnia, anxiety, and upset stomach. How can I feel Caffeine if i'm a fast caffeine metabolizer? share. Like most things, there are some people who enjoy multiple cups of coffee throughout the day whereas some can only have one. If someone is thin we often think they have a fast metabolism and if they are overweight we assume it is due to a slow metabolic rate. Slow metabolizers of caffeine may be able to reduce their risk of future health problems by modifying their intake of caffeine. Keep exercising to maintain a healthy body. That half-life is effected by whether you are a fast caffeine metabolizer or a slow caffeine metabolizer. Hypersensitivity to caffeine: These people have very low CYP1A2 activity. But fast metabolizers clear caffeine from their systems rapidly, allowing the antioxidants, polyphenols and coffee’s other healthful compounds to kick in without the side effects of caffeine, he said. Eat good food and live a stress-free life. 2. This enzyme called CYP1A2 is the also key player in whether you are a fast, or slow, caffeine metabolizer. ... you will learn whether you are a fast or slow metabolizer of caffeine. New comments cannot be posted and votes cannot be cast . I remember buying redbull to get ready for the finals, but I failed because I fell asleep after drinking. Are you a Fast or Slow Caffeine Metabolizer? of … Drinking all these different caffeinated drinks can add up and become harder for the body to breakdown, depending on your caffeine metabolism. In addition, you will know if caffeine consumed prior to endurance training will benefit you or actually possibly decrease your performance. I never felt caffeine. Namely the CYP gene family (Cytochrome P450). We all have two copies of the gene which makes up the enzyme ‘CYP1A2’, we get one copy from each parent (thanks mom & dad!). , physician and medical director at Parsley Health San Francisco , “These are the people that can have an espresso and go right to sleep!” Variations in the genes responsible for caffeine metabolism also affect how you respond to certain medicines. Or maybe a fast metabolism – and do you think you can’t change your metabolism? Caffeine is produced naturally in plants that grow cocoa beans, kola nuts, coffee beans, tea … On the other hand, fast caffeine metabolizers don’t have a higher risk of heart attacks or hypertension, and might actually see some protection from these conditions as a result of caffeine consumption! In line with the above, in a small pilot study with 21 participants, 31% of slow metabolizers (CC or AC) reported increased nervousness after caffeine ingestion, while none of the fast metabolizers (AA) reported this effect . For example, people with the so-called fast metabolizer gene are more resistant to drug therapies (clozapine) for schizophrenia (8). In my case, I know I am a slow caffeine metabolizer. They have a strong response to even small amounts of caffeine, and will commonly experience jitters and insomnia. Fast metabolizers who are heavy coffee drinkers have a 64% lower risk of high blood pressure than fast metabolizers who don’t drink any coffee. For example, variants in the CYP1A2 gene that affect the enzyme’s efficiency affect the breakdown of certain drugs. It's true what Sanjay said, I learned that I am a slow caffeine metabolizer from 23andMe's health reports. Slow metabolizers tend to drink less coffee (or other form of caffeine); fast metabolizers fuel up on more caffeine to keep feeling its effects. Slow metabolizers of caffeine who also drank at least two to three cups of coffee per day had a significantly increased risk of a non-fatal heart attack, according to research, while, according to other studies, fast metabolizers could actually reduce their heart attack risk by drinking coffee. According to this: http://snpedia.com/index.php/Rs762551 you can either be a genetically slow or a fast caffeine metabolizer. A can of Diet Coke has 46 mg of caffeine, while the Monster Energy brand of energy drinks has 160 mg per can. Everyday people across the country partake in the enjoyment of one of the most popular stimulants, coffee. According to Dr. Tiffany Lester, M.D. Genomic Express offers a genetic test that can tell you whether caffeine consumption has harmful effects on your health. But it if you have a fast metabolism, it can manifest in some interesting ways. If you have one variant of the gene, you are a fast metabolizer. You are able to burn fat and lose weight easily, while maintaining healthy muscle mass. This thread is archived. For example, if a particular CYP450 variation makes someone a rapid metabolizer of a drug, he or she may process it so fast that the drug won’t have a chance to reach optimal blood levels, leading to limited amounts of drug that can act on the patient’s system. A low or high BMR in either way is bad for your health. Caffeine – metabolism, benefits, side effects, gene interaction . Caffeine’s half-life in your body will be between 4 and 6 hours, depending on that variable. To put it simply, "metabolism is the process of converting food consumed into energy," Dr. David Greuner M.D. 100% Upvoted. Those that have a gene mutation to CYP1A2 that makes them a slow metabolizer are less likely to experience the benefits documented in the research. More temporary factors also play a role. If you know (or infer based on your symptoms) that you are a slow metabolizer, that doesn’t mean you can’t have any caffeine at all; just limit your amount and perhaps opt for tea instead of coffee. The moderate metabolizers, by … Age, gender, and body size all influence the speed of an individual’s metabolism. And for fast metabolizers under the age of … Your metabolism converts the food and beverages you consume into energy for your body. Normal sensitivity to caffeine: This is the vast majority of people.They can consume up to 400 mg of caffeine per day without adverse side effects. If the metabolic rate is low or high because of some genetic fault, there is nothing much you can do. If you are a Slow Metabolizer then your genetic makeup indicates you process caffeine at a slower rate and, as a result, caffeine may have longer-lasting stimulant effects. It is said that metabolism has to be fasted to reduce obesity. If you don’t know what is in the food, then you won’t know what you are subjecting your body to or how that food may negatively alter your now super-fast metabolism – so put that food down! In Italy, a team of scientists looked at hypertension in 553 fast and slow caffeine metabolizers. Your body will still have 1 cup of coffee’s worth of caffeine floating around inside you. These are not new facts — many of us have watched as our guy friends eat mounds of food while remaining as fit … 7 comments. If you have two “fast” versions, you’re considered a fast caffeine metabolizer. A healthy BMR is a balance that you have to maintain. Just as your parents genes determined you hair colour and eye colour, they also were responsible for your caffeine metabolism (thanks mom & dad?). But on the other hand, if someone’s metabolism is slow, then his food will be digested slowly. If drinking any caffeine makes you jittery, just cut back on quantity or drink decaf. This particular family is not only related to caffeine processing, but drug- & estrogen metabolism to name a few. WELL THINK AGAIN! If you feel wired after drinking coffee then there is a pretty good chance that you are a slow metabolizer. save hide report. One of the biggest mistakes people make is assuming you can tell if a person has a fast or slow metabolism by looking at their weight and body frame. The same amount of caffeine will, therefore, tend to have more negative effects on CYP1A2 slow metabolizers. Genetics and natural metabolism speed can influence how quickly you proces caffeine. So, if you drink 2 cups of coffee, it takes 4 to 6 hours to eliminate half the caffeine. A pharmacogenomic test, administered by your physician, can give you insights about how your body processes certain medications based on your genetic metabolism rate. Other signs that your metabolic furnace is burning bright are … So can sex; men tend to feel the effects more strongly than women. If you see A/A you are fast, A/C would be moderate, and C/C would be a slow metabolizer of caffeine and certain medications. If you ever wanted to learn how caffeine effects your body, then you’ve come to the right place. Continue to avoid all of the metabolism killers such as enriched breads, enriched pastas, refined sugars, and bad fats. Over the course of a lifetime, “your tolerance will probably change depending on a number of things,” Carpenter says. Once you know this you can adjust your daily caffeine intake based on your genes to support long term cardiovascular health. 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